Patterns of symptom improvement during antidepressant treatment of delusional depression

We assessed the pattern of changes in depressive symptoms in delusional depressed inpatients treated openly with 300 mg/day of fluvoxamine for 6 weeks. We studied 59 inpatients affected by bipolar ( n=23) and major depressive ( n=36) disorders with psychotic features (DSM-IV) who showed complete res...

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Bibliographic Details
Published in:Psychiatry research 2000-05, Vol.94 (2), p.185-190
Main Authors: Serretti, Alessandro, Lattuada, Enrico, Zanardi, Raffaella, Franchini, Linda, Smeraldi, Enrico
Format: Article
Language:English
Subjects:
Adult
Antidepressive Agents, Second-Generation - adverse effects
Antidepressive Agents, Second-Generation - therapeutic use
Anxiety
Bipolar Disorder - diagnosis
Bipolar Disorder - drug therapy
Bipolar Disorder - psychology
Cognition
Delusions - diagnosis
Delusions - drug therapy
Delusions - psychology
Depression
Depressive Disorder, Major - diagnosis
Depressive Disorder, Major - drug therapy
Depressive Disorder, Major - psychology
Female
Fluvoxamine - adverse effects
Fluvoxamine - therapeutic use
Humans
Insomnia
Longitudinal Studies
Male
Middle Aged
Personality Inventory
Psychiatric Status Rating Scales
Treatment Outcome
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Summary:We assessed the pattern of changes in depressive symptoms in delusional depressed inpatients treated openly with 300 mg/day of fluvoxamine for 6 weeks. We studied 59 inpatients affected by bipolar ( n=23) and major depressive ( n=36) disorders with psychotic features (DSM-IV) who showed complete responses to fluvoxamine treatment. Responses were evaluated using the Hamilton Rating Scale for Depression (HAMD-21, divided into: Core, Activity, Psychic anxiety, Somatic anxiety and Delusion clusters) administered at baseline and weekly until the 6th week. Random Regression Model (RRM) analysis was used to investigate the longitudinal time course of HAMD clusters. HAMD depressive symptom clusters decreased in a parallel manner from baseline to the end of the 6-week trial. The RRM analysis revealed no significant difference between HAMD clusters and the time course of the total HAMD score during treatment. Our data indicate that there is a simultaneous decrease in depressive symptoms during antidepressant treatment of delusional depressives.
ISSN:0165-1781
1872-7123
DOI:10.1016/S0165-1781(00)00139-6