Changes in brain glutathione levels during postnatal development in the rat

The concentration of glutathione in the rat cerebral cortex, cerebellum and liver was examined during postnatal development. The glutathione level in both brain regions was low at the earliest age studied (postnatal day (PND) 3) and peaked at PND7. In the liver, the glutathione level was maximal at...

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Bibliographic Details
Published in:Brain research. Developmental brain research 1996, Vol.94 (2), p.238-241
Main Authors: Nanda, Devika, Tolputt, Joanna, Collard, Keith J.
Format: Article
Language:English
Subjects:
Antioxidant
Cerebellum
Cortex
Developmental
Glutathione
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Summary:The concentration of glutathione in the rat cerebral cortex, cerebellum and liver was examined during postnatal development. The glutathione level in both brain regions was low at the earliest age studied (postnatal day (PND) 3) and peaked at PND7. In the liver, the glutathione level was maximal at PND30. The glutathione peak at PND7 occurs during a period of intense synaptogenesis and may be related to a neuroprotective role during brain development.
ISSN:0165-3806
DOI:10.1016/S0165-3806(96)80016-2