Deletion 7p in Gastric MALT Lymphoma

Deletion of the long arm of chromosome 7 has been related to loss of tumor suppressor genes which may constitute a primary step of carcinogenesis in many kinds of malignancies, including low-grade B-cell lymphoma. However, deletion of the short arm of chromosome 7, del(7p), in low-grade B-cell lymph...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2000-08, Vol.121 (1), p.86-89
Main Authors: Katayama, Yoshio, Kirizuka, Keiji, Nishizaki, Hiroshi, Nakamoto, Yoshihiko, Yamamoto, Mitsuo, Kohriyama, Kenji
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromosome Deletion
Chromosomes, Human, Pair 7 - genetics
Disease Progression
Helicobacter Infections - drug therapy
Helicobacter pylori
Hematologic and hematopoietic diseases
Humans
Karyotyping
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, B-Cell, Marginal Zone - genetics
Lymphoma, B-Cell, Marginal Zone - microbiology
Lymphoma, B-Cell, Marginal Zone - pathology
Male
Medical sciences
Middle Aged
Stomach Neoplasms - genetics
Stomach Neoplasms - microbiology
Stomach Neoplasms - pathology
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Summary:Deletion of the long arm of chromosome 7 has been related to loss of tumor suppressor genes which may constitute a primary step of carcinogenesis in many kinds of malignancies, including low-grade B-cell lymphoma. However, deletion of the short arm of chromosome 7, del(7p), in low-grade B-cell lymphoma has not been reported. Here, we report a case of gastric MALT lymphoma with the chromosome aberration del(7p) which progressed in spite of eradication of Helicobactor pylori. Deletion 7p may represent a new karyotypic change that is possibly related to autonomous growth of MALT lymphoma.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(00)00230-2