Recurring breakpoints of 1p13∼p22 in osteochondroma

Cytogenetic studies of osteochondromas are scarce but have previously shown recurring clonal aberrations involving chromosome 8. We have studied a series of eight tumors and have found recurring aberrations not only involving chromosome 8, but also chromosome 1 in five of the seven abnormal tumors....

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2002-10, Vol.138 (2), p.102-106
Main Authors: Sawyer, Jeffrey R., Thomas, Edward L., Lukacs, Janet L., Swanson, Charles M., Ding, Yiling, Parham, David M., Thomas, James R., Nicholas, Richard W.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Diseases of the osteoarticular system
Medical sciences
Tumors of striated muscle and skeleton
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Summary:Cytogenetic studies of osteochondromas are scarce but have previously shown recurring clonal aberrations involving chromosome 8. We have studied a series of eight tumors and have found recurring aberrations not only involving chromosome 8, but also chromosome 1 in five of the seven abnormal tumors. Surprisingly, three of the chromosome 1 aberrations involved pericentric inversions. Four tumors showed aberrations involving the region 1p13∼p22 by mechanisms including inversion, insertion, and translocation. These findings indicate that aberrations of chromosome 1p, in a region spanning 1p13∼p22, may be nonrandomly involved in the cytogenetic progression of osteochondroma.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(02)00598-8