Spontaneous Chromosomal Instability in Breast Cancer Families

Spontaneous chromosomal instability has been correlated with cancer predisposition. In the present study, the phenomenon has been evaluated using two cytogenetic markers, namely, frequency of spontaneous sister chromatid exchanges (SCE) and spontaneous chromosomal aberrations (CA) in peripheral bloo...

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Bibliographic Details
Published in:Cancer genetics and cytogenetics 2000-04, Vol.118 (1), p.52-56
Main Authors: Roy, Shambhu K, Trivedi, Amit H, Bakshi, Sonal R, Patel, Rashmi K, Shukla, Pina H, Patel, Shailesh J, Bhatavdekar, Jyotsna M, Patel, Devendra D, Shah, Pankaj M
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Carcinoma, Intraductal, Noninfiltrating - genetics
Carcinoma, Intraductal, Noninfiltrating - pathology
Chromosome Aberrations - genetics
Chromosome Breakage - genetics
Family Health
Female
Gene Frequency - genetics
Genetic Markers - genetics
Genetic Predisposition to Disease - genetics
Gynecology. Andrology. Obstetrics
Humans
Lymphocytes - metabolism
Lymphocytes - pathology
Mammary gland diseases
Medical sciences
Middle Aged
Mutagenesis - genetics
Sister Chromatid Exchange - genetics
Tropical medicine
Tumors
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Summary:Spontaneous chromosomal instability has been correlated with cancer predisposition. In the present study, the phenomenon has been evaluated using two cytogenetic markers, namely, frequency of spontaneous sister chromatid exchanges (SCE) and spontaneous chromosomal aberrations (CA) in peripheral blood lymphocytes of hereditary breast cancer (HBC) patients ( n = 11) and healthy blood relatives (HBR, n = 36). A statistically significant difference was observed for both the endpoints between HBC patients and controls ( P < 0.001), HBC patients and HBR ( P < 0.001), as well as HBR and controls ( P < 0.001). Thus, 63.64% of the HBC patients and 25% of HBR showed a mean CA/cell value higher than the highest mean CA/cell value of the controls (0.11 CA/cell). Similarly, 81.81% of the HBC patients and 61.11% of HBR showed a mean SCE/cell value higher than the highest mean SCE/cell value of the controls (9.60 SCE/cell). Chromosomal aberrations were more frequently observed in the B and E group of chromosomes in HBC patients and HBR. These findings primarily indicate the high level of chromosomal instability in breast cancer families, and might be one of the predisposing factors for high risk of cancer in HBR.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(99)00191-0