Modulation of opioid analgesia, tolerance and dependence by Gs-coupled, GM1 ganglioside-regulated opioid receptor functions

Studies of direct excitatory effects elicited by opioid agonists on various types of neurone have been confirmed and expanded in numerous laboratories following the initial findings reviewed previously by Stanley Crain and Ke-Fei Shen. However, the critical role of the endogenous glycolipid GM1 gang...

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 1998-09, Vol.19 (9), p.358-365
Main Authors: Crain, S M, Shen, K F
Format: Article
Language:English
Subjects:
Analgesia
Analgesics, Opioid - pharmacology
Animals
CHO Cells
Cricetinae
Drug Tolerance
G(M1) Ganglioside - pharmacology
G(M1) Ganglioside - physiology
GTP-Binding Proteins - metabolism
Humans
Narcotic Antagonists - pharmacology
Opioid-Related Disorders - etiology
Receptors, Opioid - agonists
Receptors, Opioid - drug effects
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Summary:Studies of direct excitatory effects elicited by opioid agonists on various types of neurone have been confirmed and expanded in numerous laboratories following the initial findings reviewed previously by Stanley Crain and Ke-Fei Shen. However, the critical role of the endogenous glycolipid GM1 ganglioside in regulating Gs-coupled, excitatory opioid receptor functions has not been addressed in any of the recent reviews of opioid stimulatory mechanisms. This article by Stanley Crain and Ke-Fei Shen focuses on crucial evidence that the concentration of GM1 in neurones might, indeed, play a significant role in the modulation of opioid receptor-mediated analgesia, tolerance and dependence.
ISSN:0165-6147
DOI:10.1016/s0165-6147(98)01241-3