Inhibitory monoclonal antibodies to human cytochrome P450 enzymes: a new avenue for drug discovery

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 1999-11, Vol.20 (11), p.432-438
Main Authors: Gelboin, Harry V, Krausz, Kristopher W, Gonzalez, Frank J, Yang, Tian J
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal - pharmacology
cyP450
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System - biosynthesis
Drug metabolism
Enzyme inhibition
Enzyme Inhibitors - pharmacology
Humans
Isoenzymes - antagonists & inhibitors
Isoenzymes - biosynthesis
Monoclonal antibodies
Phenotyping
Polymorphism
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ISSN:0165-6147
1873-3735
DOI:10.1016/S0165-6147(99)01382-6