Angiotensin-(1–7) reverts the stimulatory effect of angiotensin II on the proximal tubule Na +-ATPase activity via a A779-sensitve receptor

Recently, we demonstrated that the stimulatory effect of Ang II on the Na +-ATPase activity in proximal tubules is reversed, in a dose-dependent manner, by Ang-(1–7) [Biochim. Biophys. Acta 1467 (2000) 189]. In the present paper, we characterized the receptor involved in this phenomenon. The preincu...

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Bibliographic Details
Published in:Regulatory peptides 2002-01, Vol.103 (1), p.17-22
Main Authors: Lara, Lucienne S, Bica, Rafael B.S, Sena, Sı́lvia L.F, Correa, Juliana S, Marques-Fernandes, Maria F, Lopes, Anı́bal G, Caruso-Neves, Celso
Format: Article
Language:English
Subjects:
Angiotensin II
Angiotensin-(1–7)
Biological and medical sciences
Furosemide
Na +-ATPase
Proximal tubule
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Summary:Recently, we demonstrated that the stimulatory effect of Ang II on the Na +-ATPase activity in proximal tubules is reversed, in a dose-dependent manner, by Ang-(1–7) [Biochim. Biophys. Acta 1467 (2000) 189]. In the present paper, we characterized the receptor involved in this phenomenon. The preincubation of the Na +-ATPase with 10 −8 M Ang II increases the enzyme activity from 7.50±0.02 (control) to 12.40±1.50 nmol Pi mg −1 min −1 ( p
ISSN:0167-0115
1873-1686
DOI:10.1016/S0167-0115(01)00322-6