Characterization of ADAMTS14, a novel member of the ADAMTS metalloproteinase family

ADAMTS (a disintegrin-like and metalloproteinase domain with thrombospondin type 1 modules) proteins constitute a family of zinc metalloproteinases which target and process extracellular matrix proteins. We cloned and characterized a novel human ADAMTS gene, ADAMTS14, which is located on human chrom...

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Bibliographic Details
Published in:Biochimica et biophysica acta 2001-12, Vol.1522 (3), p.221-225
Main Authors: Bolz, Hanno, Ramı́rez, Alfredo, von Brederlow, Benigna, Kubisch, Christian
Format: Article
Language:English
Subjects:
ADAM Proteins
ADAMTS Proteins
ADAMTS4 Protein
Amino Acid Sequence
Chromosome 10
Chromosomes, Human, Pair 10
Cloning, Molecular
Disintegrins - chemistry
DNA, Complementary - biosynthesis
DNA, Complementary - chemistry
Endopeptidases - chemistry
Extracellular matrix
Humans
Metalloendopeptidase
Metalloendopeptidases - chemistry
Metalloendopeptidases - genetics
Metalloendopeptidases - metabolism
Molecular Sequence Data
Procollagen N-Endopeptidase - chemistry
Retina - metabolism
Thrombospondins - chemistry
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Summary:ADAMTS (a disintegrin-like and metalloproteinase domain with thrombospondin type 1 modules) proteins constitute a family of zinc metalloproteinases which target and process extracellular matrix proteins. We cloned and characterized a novel human ADAMTS gene, ADAMTS14, which is located on human chromosome 10q2. ADAMTS14 exhibits the characteristic multidomain structure of ADAMTS proteins including four thrombospondin modules and shows highest similarity to ADAMTS3 and ADAMTS2. By RT-PCR analysis we demonstrated that ADAMTS14 is expressed in human retina and also at low levels in adult brain, lung and placenta.
ISSN:0167-4781
0006-3002
1879-2634
DOI:10.1016/S0167-4781(01)00329-3