Gene structure and tissue expression of human selenoprotein W, SEPW1, and identification of a retroprocessed pseudogene, SEPW1P

We have determined that the human SEPW1 (selenoprotein W) gene maps to chromosome 19q13.3, spans approximately 6.3 kb and comprises six exons, in contrast to the previously published five exons. The gene lacks canonical TATA and CAAT boxes, but has numerous Sp1 consensus binding sites upstream of mu...

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Bibliographic Details
Published in:Biochimica et biophysica acta 2003-06, Vol.1627 (2), p.140-146
Main Authors: Bellingham, James, Gregory-Evans, Kevin, Fox, Margaret F., Gregory-Evans, Cheryl Y.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Base Sequence
Binding Sites
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 19
Exons
Gene Expression
Humans
Molecular Sequence Data
Muscle, Skeletal - physiology
Myocardium - metabolism
Organ Specificity
Promoter Regions, Genetic
Proteins - genetics
Proteins - metabolism
Pseudogene
Pseudogenes
Selenoprotein W
Selenoproteins
Sequence Homology, Nucleic Acid
Sp1 Transcription Factor - metabolism
TATA Box
Tissue expression
Transcription Initiation Site
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Summary:We have determined that the human SEPW1 (selenoprotein W) gene maps to chromosome 19q13.3, spans approximately 6.3 kb and comprises six exons, in contrast to the previously published five exons. The gene lacks canonical TATA and CAAT boxes, but has numerous Sp1 consensus binding sites upstream of multiple transcription start sites. SEPW1 is expressed in all of the 22 tissues assayed, and shows highest expression in skeletal muscle and heart. Additionally, we have also identified a retroprocessed SEPW1 pseudogene, SEPW1P, which maps to chromosome 1p34–35.
ISSN:0167-4781
0006-3002
1879-2634
DOI:10.1016/S0167-4781(03)00078-2