Molecular cloning and expression of an avian rab5 homolog

A chicken rab5 cDNA was isolated that contains the complete open reading frame for a protein of 216 amino acids, which, by comparison with available rab5 sequences from other species, is most closely related to the rab5c isoform. Two rab5 transcripts of 1.3 and 1.8 kb were detectable in various chic...

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Bibliographic Details
Published in:Biochimica et biophysica acta 1998-05, Vol.1398 (1), p.25-31
Main Authors: Bojer, Claudia D.A, Wohlrab, Franz, Ivessa, N.Erwin
Format: Article
Language:English
Subjects:
17 β-Estradiol
Amino Acid Sequence
Animals
Base Sequence
cDNA cloning
Chickens
Cloning, Molecular
DNA, Complementary
Endocytosis
Estrogens - physiology
Gallus gallus
Gene Expression
Gene Expression Regulation
GTP-Binding Proteins - genetics
Humans
Molecular Sequence Data
mRNA expression
Protein expression
rab5
rab5 GTP-Binding Proteins
Sequence Homology, Amino Acid
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Description
Summary:A chicken rab5 cDNA was isolated that contains the complete open reading frame for a protein of 216 amino acids, which, by comparison with available rab5 sequences from other species, is most closely related to the rab5c isoform. Two rab5 transcripts of 1.3 and 1.8 kb were detectable in various chicken tissues; they are abundant in tissues with high endocytic activity, such as brain, ovary, and testis. Similarly, high levels of rab5 protein expression were found in endocytotically active tissues and were increased upon estrogen treatment of roosters.
ISSN:0167-4781
0006-3002
1879-2634
DOI:10.1016/S0167-4781(98)00053-0