Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family

We have isolated a human cDNA clone from small intestine that represents a new member of the aldo-keto reductase family. This new member showed 70% identity at the protein level to human aldose reductase and around 80% identity to other Chinese hamster and mouse reductases. The expression pattern sh...

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Bibliographic Details
Published in:Biochimica et biophysica acta 1998-08, Vol.1399 (2), p.198-202
Main Authors: Hyndman, David J, Flynn, T.Geoff
Format: Article
Language:English
Subjects:
Adrenal gland
Adrenal Glands - enzymology
Alcohol Oxidoreductases - biosynthesis
Alcohol Oxidoreductases - chemistry
Alcohol Oxidoreductases - genetics
Aldehyde Reductase - chemistry
Aldehyde Reductase - genetics
Aldo-keto reductase
Aldo-Keto Reductases
Amino Acid Sequence
Base Sequence
DNA, Complementary - chemistry
DNA, Complementary - isolation & purification
Humans
Intestine, Small - enzymology
Molecular Sequence Data
RACE-PCR
Sequence
Sequence Homology, Amino Acid
Tissue distribution
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Summary:We have isolated a human cDNA clone from small intestine that represents a new member of the aldo-keto reductase family. This new member showed 70% identity at the protein level to human aldose reductase and around 80% identity to other Chinese hamster and mouse reductases. The expression pattern shows that this message is located primarily in the adrenal gland, thus suggesting an involvement in steroid metabolism. It is also strongly expressed in the intestinal tract and has been called human small intestine reductase.
ISSN:0167-4781
0006-3002
1879-2634
DOI:10.1016/S0167-4781(98)00109-2