90 Impact of vitamin D supplementation on head and neck cancer patients receiving radiotherapy

• Published in: Radiotherapy and oncology 2024-03, Vol.192, p.S100-S100
• Main Authors: Elkhouly, Enas A., Abdelghany, Achraf A, Hegazy, Amira H, Wahb, Lama K
• Format: Article
• Language: English
• Subjects: oral mucositis; radiotherapy; vitamin D
• ISSN: 0167-8140; 1879-0887
• DOI: 10.1016/S0167-8140(24)00471-7

The aim is to evaluate impact of vitamin D supplementation on oral mucositis in patients with head and neck cancer patients receiving radiotherapy with or without chemotherapy and to assess its effect on response to treatment. This is a prospective randomized clinical study conducted on sixty eight patients diagnosed as head and neck cancer that would receive either radiotherapy alone or concurrent chemo-radiotherapy at clinical oncology and nuclear medicine department, Menoufia university. Intervention group vitamin D prescribed. Control group :without vitamin D. All the patients were examined clinically weekly after the start of radiotherapy for WHO mucositis score. Response to treatment was assessed according to revised RECIST guideline (version 1.1) after 2-3 months end of treatment. Vitamin D supplementation reduced oral mucositis in head and neck cancer patients receiving radiotherapy with or without chemotherapy with significant p-value < 0.001 at week one, two, three, four, five, six and p-value was 0.042 at seventh week. Skin toxicity, taste changes and dysphagia were significantly better in intervention arm than control arm with significant P-value at week one, two, three, four, five, six and seven (0.011, 0.16, 0.001,