Low-energy light ion irradiation beam-line for radiobiological studies

In vitro radiobiological studies with ions require an extracted beam in air, uniformly spread over an area of at least 1 cm 2 characterised by a good monochromaticity. Moreover an accurate fluence monitoring is needed together to an accurate off line calibration, taking into account the measurement...

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Bibliographic Details
Published in:Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms Beam interactions with materials and atoms, 2001-04, Vol.174 (3), p.337-343
Main Authors: Scampoli, P., Casale, M., Durante, M., Grossi, G., Pugliese, M., Gialanella, G.
Format: Article
Language:English
Subjects:
Cell inactivation
High LET
Ion beams
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Summary:In vitro radiobiological studies with ions require an extracted beam in air, uniformly spread over an area of at least 1 cm 2 characterised by a good monochromaticity. Moreover an accurate fluence monitoring is needed together to an accurate off line calibration, taking into account the measurement geometry, to determine the absorbed dose. Finally energy, and then LET, following every traversed material, should be determined. In this framework we set up a facility at the 3 MV Tandem HVC TTT-3 accelerator of the University of Naples “Federico II” using light ions up to Z=6 and energy below 0.6 MeV n −1. Survival measurements of the V79 cell line following irradiation with beryllium, boron and carbon showed a good agreement with data from literature.
ISSN:0168-583X
1872-9584
DOI:10.1016/S0168-583X(00)00622-4