Hepatocyte proliferation and serum hepatocyte growth factor levels in patients with alcoholic hepatitis

Backgrounds/Methods: Hepatocyte growth factor is thought to be important in stimulating growth of the liver following injury. In this study we have measured serum levels of hepatocyte growth factor together with hepatocyte proliferation in liver biopsies, by detection of the Ki-67 antigen, in 23 pat...

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Bibliographic Details
Published in:Journal of hepatology 1996-04, Vol.24 (4), p.385-390
Main Authors: Hillan, Kenneth J., Logan, Martin C., Ferrier, Rod K., Bird, George L.A., Bennett, Gregory L., McKay, Ian C., MacSween, Roderick N.M.
Format: Article
Language:English
Subjects:
Adult
Aged
Alcohol
Antibodies, Monoclonal
Biological and medical sciences
Cell Division
Female
Gastroenterology. Liver. Pancreas. Abdomen
Hepatitis
Hepatitis, Alcoholic - blood
Hepatitis, Alcoholic - pathology
Hepatitis, Alcoholic - physiopathology
Hepatocyte growth factor
Hepatocyte Growth Factor - blood
Humans
Ki-67 Antigen - analysis
Liver - pathology
Liver - physiopathology
Liver Function Tests
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Other diseases. Semiology
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Summary:Backgrounds/Methods: Hepatocyte growth factor is thought to be important in stimulating growth of the liver following injury. In this study we have measured serum levels of hepatocyte growth factor together with hepatocyte proliferation in liver biopsies, by detection of the Ki-67 antigen, in 23 patients with alcoholic hepatitis. Results: Serum hepatocyte growth factor was elevated in all patients (median 0.9 ng/ml; range 0.6–7.7 ng/ml; normal
ISSN:0168-8278
1600-0641
DOI:10.1016/S0168-8278(96)80157-7