Effect of octreotide on systemic, central, and splanchnic haemodynamics in cirrhosis

Background/Aims: Cirrhosis with portal hypertension is associated with changes in the splanchnic and systemic haemodynamics, and subsequent complications, such as bleeding from oesophageal varices, have led to the introduction of long-acting somatostatin analogues in the treatment of portal hyperten...

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Bibliographic Details
Published in:Journal of hepatology 1997-05, Vol.26 (5), p.1026-1033
Main Authors: Møller, Søren, Brinch, Kim, Henriksen, Jens H., Becker, Ulrik
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Blood Pressure - drug effects
Central and arterial blood volume
Central circulation time
Cirrhosis
Digestive system
Female
Haemodynamics
Hemodynamics - drug effects
Hepatic blood flow
Hormones - therapeutic use
Humans
Hypertension, Portal - complications
Hypertension, Portal - physiopathology
Liver Circulation - drug effects
Liver Cirrhosis, Alcoholic - complications
Liver Cirrhosis, Alcoholic - drug therapy
Liver Cirrhosis, Alcoholic - physiopathology
Male
Medical sciences
Middle Aged
Octreotide
Octreotide - therapeutic use
Pharmacology. Drug treatments
Portal hypertension
Portal System - drug effects
Somatostatin analogue
Splanchnic Circulation - drug effects
Treatment Outcome
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Summary:Background/Aims: Cirrhosis with portal hypertension is associated with changes in the splanchnic and systemic haemodynamics, and subsequent complications, such as bleeding from oesophageal varices, have led to the introduction of long-acting somatostatin analogues in the treatment of portal hypertension. However, reports on the splanchnic and systemic effects of octreotide are contradictory and therefore the aim of the present study was to assess the effects of continuous infusion of octreotide on central and systemic haemodynamics, portal pressures, and hepatic blood flow. Methods: Thirteen patients with cirrhosis underwent liver vein catheterisation. Portal and arterial blood pressures were determined at baseline and 10, 30, and 50 min after a bolus injection of octreotide 100 μg, followed by continuous infusion of octreotide 100 μg/h for 1 h. Hepatic blood flow, cardiac output, central and arterial blood volume, and central circulation time were determined at baseline and 50 min after the start of the octreotide infusion. Results: The mean arterial blood pressure increased during the first 10 min ( p
ISSN:0168-8278
1600-0641
DOI:10.1016/S0168-8278(97)80111-0