An example of application of a mixture design with constraints to a pharmaceutical formulation

The aim of this tutorial is to show the application of a mixture experimental design to a problem of pharmaceutical formulation. A gel, based on poloxamer 407, useful for topical administration of tolfenamic acid, a potent anti-inflammatory drug very poorly soluble in water, has been prepared, and a...

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Bibliographic Details
Published in:Chemometrics and intelligent laboratory systems 2003-01, Vol.65 (1), p.139-147
Main Authors: Cafaggi, S., Leardi, R., Parodi, B., Caviglioli, G., Bignardi, G.
Format: Article
Language:English
Subjects:
Gel
Mixture experimental design
Pharmaceutical formulation
Poloxamer 407
Tolfenamic acid
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Summary:The aim of this tutorial is to show the application of a mixture experimental design to a problem of pharmaceutical formulation. A gel, based on poloxamer 407, useful for topical administration of tolfenamic acid, a potent anti-inflammatory drug very poorly soluble in water, has been prepared, and a mixture experimental design was used to study the influence of the components on the viscosity of the formulation. Its application allowed to identify a critical boundary, separating semisolid formulations from liquid ones, within a narrow interval of concentrations of the components, and to estimate their effects on the viscosity of the preparation.
ISSN:0169-7439
1873-3239
DOI:10.1016/S0169-7439(02)00045-X