Scleroderma-like reaction induced by uracil-tegafur (UFT), a second-generation anticancer agent

UFT, a combination of uracil and tegafur, is a second-generation anticancer agent. UFT has been used in Japan, other Asian countries, South America, and Russia. Recently, UFT has been extensively studied for colorectal, pancreatic, and various types of cancer in North America and Europe, especially...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2000-03, Vol.42 (3), p.519-520
Main Authors: Kono, Takeshi, Ishii, Masamitsu, Negoro, Nobuo, Taniguchi, Shoji
Format: Article
Language:English
Subjects:
Antimetabolites, Antineoplastic - adverse effects
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Scleroderma, Systemic - chemically induced
Stomach Neoplasms - drug therapy
Tegafur - adverse effects
Toxicity: skin, dermoskeleton
Uracil - adverse effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:UFT, a combination of uracil and tegafur, is a second-generation anticancer agent. UFT has been used in Japan, other Asian countries, South America, and Russia. Recently, UFT has been extensively studied for colorectal, pancreatic, and various types of cancer in North America and Europe, especially with leukovorin. We report a case of a scleroderma-like reaction induced by long-term administration of UFT. This is the first report of UFT-induced scleroderma-like reaction. (J Am Acad Dermatol 2000;42:519-20.)
ISSN:0190-9622
1097-6787
DOI:10.1016/S0190-9622(00)90233-0