Tretinoin emollient cream for photodamaged skin: Results of 48-week, multicenter, double-blind studies

Background: The ability of topical tretinoin to improve certain signs of skin photodamage has been shown previously. Objective: Our purpose was to assess the effectiveness of tretinoin emollient cream in maintaining or further improving photodamaged skin during extended use. Methods: Photodamaged su...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 1997-08, Vol.37 (2), p.217-226
Main Authors: Olsen, Elise A., Katz, H.Irving, Levine, Norman, Nigra, Thomas P., Pochi, Peter E., Savin, Ronald C., Shupack, Jerome, Weinstein, Gerald D., Lufrano, Laura, Perry, Barbara H.
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Adult
Biological and medical sciences
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Female
Humans
Keratolytic Agents - administration & dosage
Keratolytic Agents - adverse effects
Male
Medical sciences
Ointments
Pharmacology. Drug treatments
Skin - anatomy & histology
Skin - drug effects
Skin - radiation effects
Skin Aging - drug effects
Skin Aging - radiation effects
Skin, nail, hair, dermoskeleton
Tretinoin - administration & dosage
Tretinoin - adverse effects
Ultraviolet Rays - adverse effects
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Summary:Background: The ability of topical tretinoin to improve certain signs of skin photodamage has been shown previously. Objective: Our purpose was to assess the effectiveness of tretinoin emollient cream in maintaining or further improving photodamaged skin during extended use. Methods: Photodamaged subjects who completed 24 weeks of once-daily use of tretinoin emollient cream 0.05% (n = 149) or 0.01% (n = 149) continued to use the same strength formulation in a 24-week double-blind extension. Results: Maintenance of improvement or continued reduction in signs of photodamage was noted in both investigators’ and subjects’ evaluations of the 0.05% and 0.01% preparations; these results were confirmed by skin replica analyses. Cutaneous side effects were less common during the extension study than during the first 24 weeks of therapy. Conclusion: Both strengths of tretinoin emollient cream (0.05% and 0.01%) appeared safe and effective in the treatment of photodamaged skin during a 48-week treatment period. (J Am Acad Dermatol 1997;37:217-26.)
ISSN:0190-9622
1097-6787
DOI:10.1016/S0190-9622(97)80128-4