Cardiovascular Effects of Carbamazepine Toxicity

Study objective: To evaluate the cardiovascular effects of carbamazepine in patients presenting to the emergency department. Design: A retrospective case series from February 1, 1985, to July 30, 1993. Setting: Six urban EDs. Participants: Seventy-two adult and pediatric patients with serum carbamaz...

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Bibliographic Details
Published in:Annals of emergency medicine 1995-05, Vol.25 (5), p.631-635
Main Authors: Apfelbaum, Jonathan D, Caravati, E.Martin, Kerns, William P, Bossart, Philip J, Larsen, Gordon
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Carbamazepine - adverse effects
Carbamazepine - blood
Cardiovascular Diseases - chemically induced
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - physiopathology
Child
Child, Preschool
Drug toxicity and drugs side effects treatment
Electrocardiography - drug effects
Female
Heart Rate - drug effects
Humans
Incidence
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Retrospective Studies
Toxicity: cardiovascular system
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Summary:Study objective: To evaluate the cardiovascular effects of carbamazepine in patients presenting to the emergency department. Design: A retrospective case series from February 1, 1985, to July 30, 1993. Setting: Six urban EDs. Participants: Seventy-two adult and pediatric patients with serum carbamazepine concentrations greater than 12 μg/ml and concurrent 12-lead ECGs. Results: The mean carbamazepine level was 24 μg/ml (range, 12.6 to 55 μg/ml). Minor ECG abnormalities were noted but no clinically significant arrhythmias were found. No correlation was found between carbamazepine concentration and heart rate or PR, QRS, or corrected QT intervals. Four adult patients had transient hypotension. Conclusion: Clinically significant cardiovascular toxicity occurs rarely in patients with toxic carbamazepine concentrations. ECG findings do not correlate with serum carbamazepine concentration. [Apfelbaum JD, Caravati EM, Kerns WP II, Bossart PJ, Larsen G: Cardiovascular effects of carbamazepine toxicity. Ann Emerg Med May 1995;25:631-635.]
ISSN:0196-0644
1097-6760
DOI:10.1016/S0196-0644(95)70176-1