Effect of Acute Ethanol Ingestion on Orthostatic Vital Signs

Study objective: To determine the effect of acute ethanol intoxication on the results of orthostatic tilt testing. Design: Prospective, randomized crossover study. Subjects received ethanol (1.1 gm/kg) or an equal volume of water added to nonalcoholic beer. Orthostatic vital signs, ethanol concentra...

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Bibliographic Details
Published in:Annals of emergency medicine 1995-05, Vol.25 (5), p.636-641
Main Authors: Tomaszewski, Christian, Cline, David M, Whitley, Theodore W, Grant, Terry
Format: Article
Language:English
Subjects:
Adult
Alcoholic Intoxication - blood
Alcoholic Intoxication - complications
Alcoholic Intoxication - physiopathology
Biological and medical sciences
Cross-Over Studies
Dehydration - chemically induced
Drug toxicity and drugs side effects treatment
Ethanol - blood
Female
Humans
Male
Medical sciences
Miscellaneous (drug allergy, mutagens, teratogens...)
Pharmacology. Drug treatments
Posture - physiology
Prospective Studies
Pulse - physiology
Reference Values
Single-Blind Method
Tilt-Table Test
Time Factors
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Summary:Study objective: To determine the effect of acute ethanol intoxication on the results of orthostatic tilt testing. Design: Prospective, randomized crossover study. Subjects received ethanol (1.1 gm/kg) or an equal volume of water added to nonalcoholic beer. Orthostatic vital signs, ethanol concentration, and relative volume status were checked initially and hourly for 8 hours. Participants: Twenty healthy human volunteers, 10 men, and 10 women. Results: Peak ethanol concentration was 116±18 mg/dL (mean± SD) 1 hour after ingestion. ANOVA for repeated measures revealed a significant difference in orthostatic pulse changeand relative volume deficit between the ethanol and placebo groups ( P
ISSN:0196-0644
1097-6760
DOI:10.1016/S0196-0644(95)70177-X