Seizures, Ventricular Tachycardia, and Rhabdomyolysis as a Result of Ingestion of Venlafaxine and Lamotrigine

Few cases of overdoses have been described involving venlafaxine, lamotrigine, or a combination of the two agents. We describe a combined venlafaxine and lamotrigine ingestion in a patient presenting with a seizure, ventricular tachycardia, and rhabdomyolysis. We conclude that patients with overdose...

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Bibliographic Details
Published in:Annals of emergency medicine 1997-11, Vol.30 (5), p.704-708
Main Authors: Peano, Claudia, Leikin, Jerrold B, Hanashiro, Paul K
Format: Article
Language:English
Subjects:
Adult
Anticonvulsants - poisoning
Antidepressive Agents, Second-Generation - poisoning
Biological and medical sciences
Cyclohexanols - poisoning
Drug intoxications. Doping
Electrocardiography - drug effects
Humans
Lamotrigine
Male
Medical sciences
Pharmacology. Drug treatments
Rhabdomyolysis - chemically induced
Seizures - chemically induced
Seizures - drug therapy
Suicide, Attempted
Tachycardia, Ventricular - chemically induced
Triazines - poisoning
Venlafaxine Hydrochloride
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Summary:Few cases of overdoses have been described involving venlafaxine, lamotrigine, or a combination of the two agents. We describe a combined venlafaxine and lamotrigine ingestion in a patient presenting with a seizure, ventricular tachycardia, and rhabdomyolysis. We conclude that patients with overdoses that involve venlafaxine can exhibit severe cardiac effects in addition to seizures, especially if venlafaxine is combined with other agents. [Peano C, Leikin JB, Hanashiro PK: Seizures, ventricular tachycardia, and rhabdomyolysis as a result of ingestion of venlafaxine and lamotrigine. November Ann Emerg Med 1997;30:704-708.]
ISSN:0196-0644
1097-6760
DOI:10.1016/S0196-0644(97)70093-3