Derivatives of 3-cyano-6-phenyl-4-(3`-pyridyl)-pyridine-2(1H)-thione and their neurotropic activity

3-Cyano-6-phenyl-4-(3`-pyridyl)pyridine-2(1H)-thione, the related 2,2`-bis-pyridyldisulfide, 2-alkylthiopyridines and 2-aminothieno[2,3-b]pyridines were synthesised and their neurotropic activities were examined. Bispyridyldisulfide exhibited low toxicity (LD 50 > 5 000 mg/kg, ICR mice, i.p.) and...

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Published in:European journal of medicinal chemistry 1999-04, Vol.34 (4), p.301-310
Main Authors: Krauze, Aivars, Ģērmane, Skaidrite, Eberlin |nE š, Ojārs, Šturms, Igors, Klusā, Vija, Duburs, Gunárs
Format: Article
Language:English
Subjects:
1,2-dihydro-2-thioxopyridine-3-carbonitrile
antiamnesic agent
Biological and medical sciences
bispyridyldisulfide
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
thieno[2,3-b]pyridine
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Summary:3-Cyano-6-phenyl-4-(3`-pyridyl)pyridine-2(1H)-thione, the related 2,2`-bis-pyridyldisulfide, 2-alkylthiopyridines and 2-aminothieno[2,3-b]pyridines were synthesised and their neurotropic activities were examined. Bispyridyldisulfide exhibited low toxicity (LD 50 > 5 000 mg/kg, ICR mice, i.p.) and selective antiamesic activity at the doses of 0.05–0.5 mg/kg p.o. This effect was significantly higher than that induced by Piracetam at 50 mg/kg.
ISSN:0223-5234
1768-3254
DOI:10.1016/S0223-5234(99)80081-6