Experimental and clinical study on the hypolipidemic and antisclerotic effect of Lactobacillus Bulgaricus strain GB N 1 (48)

The study aims to perform experimental and clinical testing of the effect of the milk product “Bulgaricum” containing Lactobacillus Bulgaricus (LB) strain GB N 1 (48) on the progress and severity of experimental model of hyperlipidemia and sclerotic processes serum lipids and blood flow in aa. carot...

Full description

Saved in:
Bibliographic Details
Published in:Nutrition research (New York, N.Y.) N.Y.), 2002-04, Vol.22 (4), p.393-403
Main Authors: Doncheva, Nadezhda Iv, Antov, Georgi P, Softova, Ekaterina B, Nyagolov, Yuri P
Format: Article
Language:English
Subjects:
aorta
Atherosclerosis
Biological and medical sciences
blood flow
blood lipids
collagen
diet
Dyslipoproteinemia
electron microscopy
General pharmacology
humans
hyperlipidemia
Lactobacillus Bulgaricus
Lactobacillus delbrueckii subsp. bulgaricus
Medical sciences
milk
myocardial ischemia
myocardium
people
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Probiotic
rats
Sonography
ultrasonography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The study aims to perform experimental and clinical testing of the effect of the milk product “Bulgaricum” containing Lactobacillus Bulgaricus (LB) strain GB N 1 (48) on the progress and severity of experimental model of hyperlipidemia and sclerotic processes serum lipids and blood flow in aa. carotides in persons with dyslipoproteinemia (DLP). Histological and electron microscopic examinations of the components of the major intercellular matrix of rat myocardium and aorta slices evidence the combination of atherogenic diet and the milk product “Bulgaricum” leads to a delayed synthesis of collagen proteins, a tendency of decreased deposition of insoluble collagen, and improved ratio of unsulfated and sulfated glucoseaminoglycanes. Doppler sonography, and serum lipids studies in 26 individuals with DLP and ischaemic heart disease after 3 months supplementation with the product indicated substantial decrease of TC and LDL-Chol. The milk product “Bulgaricum” has hypolipidemic and antiatherosclerotic effect in humans and animals.
ISSN:0271-5317
1879-0739
DOI:10.1016/S0271-5317(01)00397-9