Calcium in mineral water can effectively suppress parathyroid function and bone resorption

• Published in: Nutrition research (New York, N.Y.) N.Y.), 2002, Vol.22 (8), p.901-910
• Main Authors: Guillemant, Josette, Accarie, Chantal, de la Guéronnière, Viviane, Guillemant, Serge
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; blood serum; Bone markers; Bone resorption; Calcium; collagen; Cross-Laps; crosslinking; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; ingestion; ionization; men; Mineral water; parathyroid hormone; t-test; tricalcium phosphate; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 0271-5317; 1879-0739
• DOI: 10.1016/S0271-5317(02)00403-7

The present study was designed to measure the effects, on parathyroid function and bone metabolism, of ingestion of high-calcium mineral water and of a calcium salt bringing the same dose (600 mg) of calcium as a reference. Fifteen healthy young men (mean ± SD age : 23.3 ± 1.2) ingested, during 3 different experimental periods chosen at random, a) high-calcium mineral water (596 mg/L), b) low-calcium mineral water as a control assay, c) one bag of tricalcium phosphate powder containing 600 mg of calcium. Serum concentrations of ionized calcium (iCa), intact parathyroid hormone (iPTH) and of a biochemical marker of bone resorption, type I collagen cross-linked C telopeptide (CTX), were measured before 08.00 and every hour from 09.00 to 17.00. Serum iCa concentrations were significantly ( P < 0.0001) higher and serum iPTH concentrations were significantly ( P < 0.01) lower after oral intake of both high-calcium water and tricalcium phosphate than in control period. Serum concentrations of CTX were significantly lower after either high-calcium water ( P < 0.0001) or tricalcium phosphate ( P = 0.011) than in the control period and a statistically significant difference ( P < 0.05) using Bonferroni t test between the effects of high-calcium mineral water and of tricalcium phosphate was observed from 14.00 to 17.00. The same total amount of calcium (# 600 mg) from one liter of high-calcium mineral water, divided into three intakes, at 3 hours intervals, resulted in a more prolonged suppression of serum CTX, than from the ingestion of a calcium salt.