Serum amino acid and myofibrillar protein profiles of fed and underfed laboratory rats

This work aims at the determination of serum free amino acid and myofibrillar protein profiles in the fed and underfed state of the rat. Sixteen male rats were divided in 2 groups: CR (control) fed ad libitum and RR (restricted feeding) fed 34% energetic maintenance needs. Animals were slaughtered a...

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Bibliographic Details
Published in:Nutrition research (New York, N.Y.) N.Y.), 2002-12, Vol.22 (12), p.1453-1459
Main Authors: Almeida, A.M, van Harten, S, Cardoso, L.A
Format: Article
Language:English
Subjects:
amino acids
Biological and medical sciences
blood serum
free amino acids
males
malnutrition
Medical sciences
Metabolic diseases
metabolism
muscles
Myofibrillar proteins
Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)
Rat
rats
restricted feeding
Serum free amino acids
Undernutrition
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Summary:This work aims at the determination of serum free amino acid and myofibrillar protein profiles in the fed and underfed state of the rat. Sixteen male rats were divided in 2 groups: CR (control) fed ad libitum and RR (restricted feeding) fed 34% energetic maintenance needs. Animals were slaughtered at day 23, bled and serum free amino acid profile determined. Gastrocnemius muscle was taken for myofibrillar protein characterisation. Although higher concentrations of Ile, Thr, Met, Ser and Cys were observed in RR group, no preferable catabolism of individual amino acids was observed in undernourished rats in this study. Myofibrillar protein profiles were similar in both groups revealing the lack of preferable catabolism of myofibrillar proteins and consequently keeping muscle structure.
ISSN:0271-5317
1879-0739
DOI:10.1016/S0271-5317(02)00472-4