Breath 13CO2 enrichment in obese women during the fasting and the fed states

The objective of the present study was to assess by isotope ratio mass spectrometry the breath 13CO2 enrichment in obese women during the fasting and the fed states and to correlate it with blood 13CO2 enrichment. Eight obese women aged 30 +/- 6 years (mean +/- SD), body mass index of 40 +/- 8 kg/m2...

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Bibliographic Details
Published in:Nutrition research (New York, N.Y.) N.Y.), 2003-09, Vol.23 (9), p.1153-1163
Main Authors: Suen, Vivian M.M, Unamuno, Maria R.D.L, Marchini, J. Sergio
Format: Article
Language:English
Subjects:
biochemical pathways
Biological and medical sciences
blood
body mass index
carbon dioxide
fasting
ingestion
intravenous injection
isotopes
mass spectrometry
Medical sciences
Metabolic diseases
Obesity
women
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Summary:The objective of the present study was to assess by isotope ratio mass spectrometry the breath 13CO2 enrichment in obese women during the fasting and the fed states and to correlate it with blood 13CO2 enrichment. Eight obese women aged 30 +/- 6 years (mean +/- SD), body mass index of 40 +/- 8 kg/m2 were submitted to intravenous infusion of 13NaHCO3 for eight hours. During the first four hours the subjects fasted and during the subsequent four hours they ingested 1 meal per hour. Breath 13CO2 enrichment (XCO2) was 0.72 +/- 0.12 during fasting and 0.75 +/- 0.14 during feeding (P > 0.5, non parametric Wilcoxon test). Blood 13CO2 enrichment was higher during food ingestion (0.61 +/- 0.14 against 0.51 +/- 0.14 in the fasted state, P = 0.0078). We conclude that breath 13CO2 enrichment was not different under fasting and fed conditions. The greater blood enrichment during feeding was not accompanied by greater breath enrichment, indicating that CO2 is shifted to other metabolic pathways.
ISSN:0271-5317
1879-0739
DOI:10.1016/S0271-5317(02)00537-7