Iron intake affects lipid peroxidation and glutathione peroxidase activity of distal colonic mucosa

The purpose of this study was to examine the effect of low, adequate, and high dietary iron (Fe) levels on lipid peroxidation, glutathione S-transferase (GST) and glutathione peroxidase (GSH-Px) activities, and glutathione (GSH) concentrations in colon and liver. Male Sprague Dawley rats were fed ir...

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Bibliographic Details
Published in:Nutrition research (New York, N.Y.) N.Y.), 1997-11, Vol.17 (11), p.1683-1691
Main Authors: Stimson, J., Fischer, J.G.
Format: Article
Language:English
Subjects:
ACTIVIDAD ENZIMATICA
ACTIVITE ENZYMATIQUE
ANIMAL MODELS
Biological and medical sciences
BODY WEIGHT
Colonic mucosa
DIET
DIETA
DOSAGE EFFECTS
EFECTOS DE DOSIFICACION
EFFET DOSE
ENZYMIC ACTIVITY
EXPERIMENTACION
EXPERIMENTATION
Feeding. Feeding behavior
FER
FOIE
FOOD INTAKE
Fundamental and applied biological sciences. Psychology
GLUTATHION
GLUTATHION PEROXYDASE
GLUTATHIONE
GLUTATHIONE PEROXIDASE
Glutathione S-transferase
GLUTATHIONE TRANSFERASE
GLUTATION
GLUTATION PEROXIDASA
HEMATOCRIT
HIERRO
HIGADO
INGESTION DE ALIMENTOS
INGESTION DE NUTRIENTES
INGESTION DE SUBSTANCES NUTRITIVES
INSTRUMENT DE MESURE
INSTRUMENTOS DE MEDICION
INTESTIN
INTESTINES
INTESTINOS
IRON
Iron intake
LIPID PEROXIDATION
LIVER
MEASURING INSTRUMENTS
MEMBRANA MUCOSA
MODELE ANIMAL
MODELOS ANIMALES
MUCOUS MEMBRANE
MUQUEUSE
NUTRIENT INTAKE
PEROXIDACION LIPIDICA
PEROXYDATION DES LIPIDES
PESO CORPORAL
POIDS CORPOREL
PRISE ALIMENTAIRE (HOMME)
PROXIMAL COLON
RAT
RATA
RATS
REGIME ALIMENTAIRE
TRANSFERASAS
TRANSFERASE
TRANSFERASES
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:The purpose of this study was to examine the effect of low, adequate, and high dietary iron (Fe) levels on lipid peroxidation, glutathione S-transferase (GST) and glutathione peroxidase (GSH-Px) activities, and glutathione (GSH) concentrations in colon and liver. Male Sprague Dawley rats were fed iron deficient (DFe; 14 mg Fe/kg diet; n=8), adequate iron (AFe; 39 mg Fe/kg diet, n=8), or high iron (HFe; 454 mg Fe/kg diet; n=8) diets for 3 weeks. Liver Fe concentrations were 26, 84, and 243 ug/g wet weight, respectively, for rats fed DFe, AFe, and HFe diets (p
ISSN:0271-5317
1879-0739
DOI:10.1016/S0271-5317(97)00175-9