Crystal structure and antitumor activity of some rare earth metal complexes with Schiff base

The ligand 1-phenyl-3-methyl-5-hydroxy-4-pyrazolyl phenyl ketone (PMBP) isonicotinoyl hydrazone (H 2L) was prepared by condensation of PMBP with isoniazid. Seven complexes of rare earth metals with H 2L were synthesized and characterized on the basis of elemental analyses, IR, UV, 1H NMR spectra and...

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Bibliographic Details
Published in:Polyhedron 2000, Vol.19 (26), p.2599-2604
Main Authors: Yang, Zheng-Yin, Yang, Ru-Dong, Li, Fa-Shen, Yu, Kai-Bei
Format: Article
Language:English
Subjects:
Antitumour activity
Crystal structure
Hydrazone
Rare earth complex
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Summary:The ligand 1-phenyl-3-methyl-5-hydroxy-4-pyrazolyl phenyl ketone (PMBP) isonicotinoyl hydrazone (H 2L) was prepared by condensation of PMBP with isoniazid. Seven complexes of rare earth metals with H 2L were synthesized and characterized on the basis of elemental analyses, IR, UV, 1H NMR spectra and thermal analyses. The general formula of the complexes is Ln(HL) 3·3.5H 2O (where Ln(III)=La, Eu, Gd, Tb, Dy, Ho and Er). X-ray diffraction analysis showed that the coordination polyhedron of the Eu complex is a tricapped trigonal prism. The La and Eu complexes possess antitumor activity, and the inhibitory rates for leukemia cells (L 1210) are 87.1% and 78.5%, respectively.
ISSN:0277-5387
DOI:10.1016/S0277-5387(00)00562-3