Reduction of motor seizures in rats induced by the ethyl bicyclophosphate trimethylolpropane phosphate (TMPP)

1. Trimethylolpropane phosphate (TMPP) is a potent cage convulsant, reported to act through binding to the picrotoxinin and/or benzodiazepine receptor sites of the gamma-aminobutyric A (GABA A) ionophore complex. 2. Adult male Fischer-344 rats were pretreated by intraperitoneal (ip) injection with e...

Full description

Saved in:
Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 2001-08, Vol.25 (6), p.1323-1340
Main Authors: Rossi, John, Ritchie, Glenn D., McInturf, Shawn, Nordholm, Alan F.
Format: Article
Language:English
Subjects:
Animals
anticonvulsants
Anticonvulsants - therapeutic use
Biological and medical sciences
Bridged Bicyclo Compounds, Heterocyclic - adverse effects
bridged organophosphate
cage convulsant
Chemical and industrial products toxicology. Toxic occupational diseases
Convulsants - adverse effects
ethyl bicyclophosphate
GABA
glutamate
Male
Medical sciences
motor seizures
Rats
Rats, Inbred F344
Receptors, GABA - physiology
Seizures - chemically induced
Seizures - drug therapy
Seizures - physiopathology
Toxicology
trimethylolpropane phosphate
Various organic compounds
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:1. Trimethylolpropane phosphate (TMPP) is a potent cage convulsant, reported to act through binding to the picrotoxinin and/or benzodiazepine receptor sites of the gamma-aminobutyric A (GABA A) ionophore complex. 2. Adult male Fischer-344 rats were pretreated by intraperitoneal (ip) injection with either diazepam (DZP) [0.5–5.0 mg/kg], Phenobarbital (PB) [5–20 mg/kg], dizocilpine maleate (MK-801) [0.5–3.0 mg/kg], Tiagabine (TGB) [0.5–5.0 mg/kg], 6,7-dinitro-quinoxaline-2,3-dione (DNQX), [5–20 mg/kg], or scopolamine [SCP] (0.25–1.0 mg/kg) 30 min prior to ip injection with a convulsive dose of TMPP (0.6 mg/kg). 3. Rats were rated for occurrence of convulsive activity for 120 min post-injection. Time from TMPP injection to observation of subclinical seizures, generalized (tonic-clonic) seizures, and lethality was rated for each pretreatment group. 4. In general, DZP = PB > TGB in reduction of TMPP subclinical and/or clinical seizures. MK-801, at dose levels inducing near sedation, was also effective in modulation of TMPP-induced seizures. SCP or DNQX were generally ineffective in reducing or eliminating TMPP-induced seizures.
ISSN:0278-5846
1878-4216
DOI:10.1016/S0278-5846(01)00182-8