Strain differences in haematological response to chloroamphenicol succinate in mice: implications for toxicological research

Much toxicological research continues to be done using genetically undefined “outbred” stocks of mice and rats, although the case for using isogenic strains has been made repeatedly in the literature over a period of more than two decades. Also, very few studies are conducted using more than one str...

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Bibliographic Details
Published in:Food and chemical toxicology 2001-04, Vol.39 (4), p.375-383
Main Authors: Festing, M.F.W., Diamanti, P., Turton, J.A.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chloramphenicol succinate
General aspects. Methods
Genetic variation
Haemotoxicity
Inbred strains
Medical sciences
Mouse
Principal components analysis
Toxicology
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Summary:Much toxicological research continues to be done using genetically undefined “outbred” stocks of mice and rats, although the case for using isogenic strains has been made repeatedly in the literature over a period of more than two decades. Also, very few studies are conducted using more than one strain, with the result that genetic variation in response is seldom apparent to the investigator. Here we report qualitative and quantitative strain differences in the haematological response to chloramphenicol succinate (CAPS) when administered by gavage at 500–2500 mg/kg for 7 days, to four inbred strains of mouse (C3H/He, CBA/Ca, BALB/c and C57BL/6) and one outbred stock (CD-1). CAPS caused anaemia and reticulocytopenia in all mouse strains, and leucopenia in the inbred strains but not in the outbred CD-1 stock. All four inbred strains showed significant ( P
ISSN:0278-6915
1873-6351
DOI:10.1016/S0278-6915(00)00149-6