The activities of tissue xanthine oxidase and adenosine deaminase and the levels of hydroxyproline and nitric oxide in rat hearts subjected to doxorubicin: protective effect of erdosteine

The aim of this experimental study was to investigate the effects of erdosteine, an antioxidant agent, on doxorubicin (DXR)-induced cardio-toxicity through nitric oxide (NO) levels, collagen synthesis, xanthine oxidase (XO) and adenosine deaminase (ADA) activities in rats. Rats were treated with erd...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2003-09, Vol.191 (2), p.153-158
Main Authors: Fadillioglu, Ersin, Yılmaz, H.Ramazan, Erdogan, Hasan, Sogut, Sadik
Format: Article
Language:English
Subjects:
Adenosine deaminase
Adenosine Deaminase - metabolism
Animals
Antibiotics, Antineoplastic - antagonists & inhibitors
Antibiotics, Antineoplastic - toxicity
Antioxidants - pharmacology
Cardiomyopathies - chemically induced
Cardiomyopathies - enzymology
Cardiomyopathies - metabolism
Cardiomyopathies - prevention & control
Doxorubicin
Doxorubicin - antagonists & inhibitors
Doxorubicin - toxicity
Erdosteine
Hydroxyproline
Hydroxyproline - metabolism
Male
Nitric oxide
Nitric Oxide - metabolism
Random Allocation
Rats
Rats, Sprague-Dawley
Thioglycolates - pharmacology
Thiophenes - pharmacology
Xanthine oxidase
Xanthine Oxidase - metabolism
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Summary:The aim of this experimental study was to investigate the effects of erdosteine, an antioxidant agent, on doxorubicin (DXR)-induced cardio-toxicity through nitric oxide (NO) levels, collagen synthesis, xanthine oxidase (XO) and adenosine deaminase (ADA) activities in rats. Rats were treated with erdosteine (10 mg/kg b.wt. per day, orally) or saline starting 2 days before administrating a single dose of DXR (20 mg/kg i.p.) or saline. At the 10th day of the DXR administration, hearts were removed under anesthesia for biochemical measurements. Enzyme activities as well as OH-proline and NO levels were found to be significantly increased in DXR group compared with the control group. All of the parameters studied except ADA activity were decreased significantly approximating to the control levels upon erdosteine administration. In conclusion, erdosteine seems to be an alternative agent for protection of cardiac tissue against DXR-induced cardio-toxicity through its regulatory effect on XO activity and NO level.
ISSN:0300-483X
1879-3185
DOI:10.1016/S0300-483X(03)00258-0