Mapping of a new target region of allelic loss at 21q22 in primary gastric cancers

To determine the minimal region of deletion on 21q22 in gastric cancer, we performed a high-density loss of heterozygosity (LOH) study with eight polymorphic microsatellite markers. Among the 43 tumors examined, 20 (50%) of 40 informative carcinomas showed LOH at one or more loci. The peak LOH frequ...

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Bibliographic Details
Published in:Cancer letters 2000-10, Vol.159 (1), p.15-21
Main Authors: Park, Won Sang, Oh, Ro Ra, Park, Jik Young, Yoo, Nam Jin, Lee, Sug Hyung, Shin, Min Sun, Kim, Su Young, Kim, Young Sil, Lee, Jong Heun, Kim, Hong Sug, An, Won Gun, Lee, Jung Young
Format: Article
Language:English
Subjects:
21q22
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Biological and medical sciences
Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 21 - genetics
DNA, Neoplasm - genetics
Gastric cancer
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Loss of Heterozygosity
Medical sciences
Microsatellite Repeats
Stomach Neoplasms - genetics
Stomach Neoplasms - pathology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:To determine the minimal region of deletion on 21q22 in gastric cancer, we performed a high-density loss of heterozygosity (LOH) study with eight polymorphic microsatellite markers. Among the 43 tumors examined, 20 (50%) of 40 informative carcinomas showed LOH at one or more loci. The peak LOH frequency was identified at D21S1820 (34.2%) in 21q22.3. This data suggests that this locus might harbor a new tumor suppressor gene in an area
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(00)00525-5