Whole almonds and almond fractions reduce aberrant crypt foci in a rat model of colon carcinogenesis

• Published in: Cancer letters 2001-04, Vol.165 (1), p.27-33
• Main Authors: Davis, Paul A., Iwahashi, Christine K.
• Format: Article
• Language: English
• Subjects: Aberrant crypt foci; Almonds; Animals; Azoxymethane; Biological and medical sciences; Body Weight - drug effects; Carcinogenesis, carcinogens and anticarcinogens; Choristoma - drug therapy; Colon cancer; Colonic Neoplasms - chemically induced; Colonic Neoplasms - prevention & control; Diet; Disease Models, Animal; Foods and miscellaneous; High fat diet; Male; Medical sciences; Nuts - therapeutic use; Organ Size - drug effects; Phytotherapy; Plant Oils - therapeutic use; Rats; Rats, Inbred F344; Rodent; Tumors
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/S0304-3835(01)00425-6

Almonds and other nuts appear to confer health benefits despite their high fat content. To assess the effect of almonds on colon cancer, whole almond-, almond meal- or almond oil-containing diet effects on aberrant crypt foci (ACF) in azoxymethane-treated F344 male rats were investigated. Six-week-old male F344 rats were fed the various almond and control diets and given subcutaneous injections of azoxymethane (15 mg/kg body weight) twice 1 week apart. After 26 weeks animals were injected with bromodeoxyuridine 1 h prior to sacrifice, after which colons were evaluated for ACF and cell turnover (labeling index, LI). Whole almond ACF and LI were both significantly lower than wheat bran and cellulose diet groups (−30 and −40%, respectively), while almond meal and almond oil ACF and almond meal LI declines were only significant vs. cellulose ( P