Macrophage migration inhibitory factor in hepatocellular carcinoma and liver cirrhosis; relevance to pathogenesis

The levels of macrophage migration inhibitory factor (MIF), a proinflammatory and carcinogenic cytokine, were significantly higher in the sera from patients with hepatocellular carcinoma (HCC; 25.6±15.3 ng/ml, n=55) and liver cirrhosis (LC; 18.9±10.7 ng/ml, n=26) compared with sera from patients wit...

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Bibliographic Details
Published in:Cancer letters 2001-10, Vol.171 (2), p.125-132
Main Authors: Akbar, S.M.Fazle, Abe, Masanori, Murakami, Hidehiro, Tanimoto, Kenji, Kumagi, Teru, Yamashita, Yoshimasa, Michitaka, Kojiro, Horiike, Norio, Onji, Morikazu
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - pathology
Cell culture
Cells, Cultured
Female
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal Neoplasms - blood
Hepatitis, Chronic - blood
Hepatocellular carcinoma
Hepatocytes - metabolism
Humans
Immunohistochemistry
Leukocytes, Mononuclear - metabolism
Liver cirrhosis
Liver Cirrhosis - blood
Liver Cirrhosis - pathology
Liver Neoplasms - blood
Liver Neoplasms - etiology
Liver Neoplasms - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Macrophage Migration-Inhibitory Factors - biosynthesis
Macrophage Migration-Inhibitory Factors - blood
Male
Medical sciences
Middle Aged
Migration inhibitory factor
Tumors
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Summary:The levels of macrophage migration inhibitory factor (MIF), a proinflammatory and carcinogenic cytokine, were significantly higher in the sera from patients with hepatocellular carcinoma (HCC; 25.6±15.3 ng/ml, n=55) and liver cirrhosis (LC; 18.9±10.7 ng/ml, n=26) compared with sera from patients with gastrointestinal cancer (6.8±7.5 ng/ml, n=29) and normal controls (5.6±1.2 ng/ml, n=45; P
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(01)00606-1