Cancer chemopreventive agents, serratane-type triterpenoids from Picea jezoensis

Seven serratane-type triterpenoids isolated from the cuticle of Picea jezoensis (Sieb. et Zucc.) Carr. jezoensis (Pinaceae) and the stem bark of Picea jezoensis (Sieb. et Zucc.) Carr. hondoensis (Mayer) Rehder (Pinaceae) were studied their possible inhibitory effects on Epstein-Barr virus early anti...

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Bibliographic Details
Published in:Cancer letters 2001-10, Vol.172 (2), p.119-126
Main Authors: TANAKA, Reiko, MINAMI, Toshifumi, TSUJIMOTO, Kazuhiro, MATSUNAGA, Shunyo, TOKUDA, Harukuni, NISHINO, Hoyoku, TERADA, Yukimasa, YOSHITAKE, Akira
Format: Article
Language:English
Subjects:
9,10-Dimethyl-1,2-benzanthracene
Animals
Anticarcinogenic Agents - pharmacology
Antigens, Viral - drug effects
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Chemical agents
Female
Humans
Medical sciences
Mice
Mice, Inbred ICR
Papilloma - chemically induced
Papilloma - prevention & control
Plants - chemistry
Skin Neoplasms - chemically induced
Skin Neoplasms - prevention & control
Tetradecanoylphorbol Acetate
Triterpenes - pharmacology
Tumors
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Summary:Seven serratane-type triterpenoids isolated from the cuticle of Picea jezoensis (Sieb. et Zucc.) Carr. jezoensis (Pinaceae) and the stem bark of Picea jezoensis (Sieb. et Zucc.) Carr. hondoensis (Mayer) Rehder (Pinaceae) were studied their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). All compounds showed strong inhibitory effects on the EBV-EA activation, being stronger than that of oleanolic acid, which exerts on cancer preventive activity in animal carcinogenesis models. Among these compounds, 13alpha, 14alpha-epoxy-3beta-methoxyserratan-21beta-ol and 3beta-methoxy-21alpha-hydroxyserrat-14-en-29-al were investigated for the inhibitory effects in a two-stage mouse skin carcinogenesis test on mouse skin using 7,12-dimethylbenz[a]anthracene as initiator and TPA as promoter. 13alpha,14alpha-Epoxy-3beta-methoxyserratan-21beta-ol was found to exhibit the excellent anti-tumor promoting activity in the in vivo carcinogenesis test.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(01)00650-4