Cytogenetic damage in exfoliated oral mucosal cells and circulating lymphocytes of patients suffering from precancerous oral lesions

One hundred patients suffering from oral submucous fibrosis (OSF), oral leukoplakia (OL) and oral lichen planus (OLP) were studied for the cytogenetic damage in oral mucosal cells and in circulating lymphocytes along with their habit patterns. It was observed that OSF was largely associated with bet...

Full description

Saved in:
Bibliographic Details
Published in:Cancer letters 1996-12, Vol.109 (1), p.9-14
Main Authors: Desai, S.S., Ghaisas, S.D., Jakhi, S.D., Bhide, S.V.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Areca
Biological and medical sciences
Circulating lymphocytes
Cytogenetic damage
DNA Damage
Female
Fibrosis - epidemiology
Fibrosis - pathology
Humans
India - epidemiology
Leukoplakia, Oral - epidemiology
Leukoplakia, Oral - pathology
Lichen Planus - epidemiology
Lichen Planus - pathology
Lymphocytes - pathology
Male
Medical sciences
Micronucleus Tests
Middle Aged
Mouth Diseases - epidemiology
Mouth Diseases - pathology
Mouth Mucosa - pathology
Mouth Neoplasms - epidemiology
Mouth Neoplasms - pathology
Oral lesions
Oral mucosal cells
Otorhinolaryngology. Stomatology
Plants, Medicinal
Precancerous Conditions - epidemiology
Precancerous Conditions - pathology
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:One hundred patients suffering from oral submucous fibrosis (OSF), oral leukoplakia (OL) and oral lichen planus (OLP) were studied for the cytogenetic damage in oral mucosal cells and in circulating lymphocytes along with their habit patterns. It was observed that OSF was largely associated with betel nut containing masticants while OL was associated with chewing or smoking habit. It was further observed that their exfoliated oral mucosal cells had significantly higher numbers of micronucleated (Mn) cells as compared to those of healthy normal subjects without any chewing or smoking habit. Similar cytogenetic damage in the form of increased sister chromatid exchanges (SCE) was observed in circulating lymphocytes indicating that the carcinogenic agents produce damage not only in target tissue but also in other host cells such as circulating lymphocytes.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(96)04390-X