Antimutagenic activity of anthocyanins isolated from Aronia melanocarpa fruits

Anthocyanins belong to the flavonoid family and are ubiquitous in plants, especially in flower petals and fruit peels. We established that anthocyanins isolated from fruits of Aronia melanocarpa markedly inhibited the mutagenic activity of benzo( a)pyrene and 2-amino fluorene in the Ames test. In th...

Full description

Saved in:
Bibliographic Details
Published in:Cancer letters 1997-10, Vol.119 (1), p.37-46
Main Authors: Ga̧siorowski, Kazimierz, Szyba, Katarzyna, Brokos, Barbara, Koz.xl, laczyńska, Beata, Jankowiak-Wz.xl, lodarczyk, Magda, Oszmiański, Jan
Format: Article
Language:English
Subjects:
Anthocyanins
Anthocyanins - chemistry
Anthocyanins - pharmacology
Antimutagenic activity
Antimutagenic Agents - pharmacology
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Cell Proliferation - drug effects
DNA - drug effects
Foods and miscellaneous
Free radicals scavenging
Fruit - chemistry
Humans
Lymphocytes - drug effects
Medical sciences
Mutagenicity Tests
Photinia - chemistry
Plant Extracts - chemistry
Plant Extracts - pharmacology
Sister Chromatid Exchange - drug effects
Superoxides
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Anthocyanins belong to the flavonoid family and are ubiquitous in plants, especially in flower petals and fruit peels. We established that anthocyanins isolated from fruits of Aronia melanocarpa markedly inhibited the mutagenic activity of benzo( a)pyrene and 2-amino fluorene in the Ames test. In the Sister Chromatid Exchanges (SCEs) test with human blood-derived lymphocytes cultured in vitro, a significant decrease of SCEs frequency induced by benzo( a)pyrene was observed in the presence of anthocyanins. In the case of mitomycin C the effect of anthocyanins on SCEs frequency was smaller but still noticeable. Anthocyanins markedly inhibited the generation and release of superoxide radicals by human grartulocytes. The results suggest that the antimutagenic influence of anthocyanins is exerted mainly by their free-radicals scavenging action as well as by the inhibition of enzymes activating promutagens and converting mutagens to the DNA-reacting derivatives. These preliminary data seem to be important in the aspect of a possible antimutagenic and anticarcinogenic potency of anthocyanins commonly present in fruits and vegetables.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(97)00248-6