Experimental evidence for cancer preventive elements in foods

The last decade has witnessed an incredible advance in our understanding of how fruits and vegetables work to prevent cancer. Epidemiological studies have suggested that a diet rich in fruits and vegetables is associated with reduced risk for a number of common cancers. Food chemists and natural pro...

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Bibliographic Details
Published in:Cancer letters 1997-03, Vol.114 (1), p.11-17
Main Author: Wargovich, Michael J.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Calcium - pharmacology
Cancer chemoprevention
Carcinogen metabolism
Carcinogenesis, carcinogens and anticarcinogens
Carcinogens - antagonists & inhibitors
Carcinogens - metabolism
Carotenoids - pharmacology
Cell Division - drug effects
Cellular proliferation
Colonic Neoplasms - prevention & control
Curcumin - pharmacology
Cytochrome P-450 CYP2E1 Inhibitors
Diet
DNA adducts
DNA Adducts - metabolism
Ellagic Acid - pharmacology
Esophageal Neoplasms - prevention & control
Foods
Foods and miscellaneous
Fruit
Medical sciences
Oncogenes
Pancreatic Neoplasms - prevention & control
ras Proteins - antagonists & inhibitors
Reactive Oxygen Species
Skin Neoplasms - prevention & control
Tea
Terpenes - pharmacology
Tumors
Vegetables
Vitamin D - pharmacology
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Summary:The last decade has witnessed an incredible advance in our understanding of how fruits and vegetables work to prevent cancer. Epidemiological studies have suggested that a diet rich in fruits and vegetables is associated with reduced risk for a number of common cancers. Food chemists and natural product scientists have identified hundreds of ‘phytochemicals’ that are being evaluated for the prevention of cancer. Food components can modify carcinogenesis in one of five different ways. They may: (1) modify carcinogen activation by inhibiting Phase 1 enzymes; (2) modify how carcinogens are detoxified through Phase 2 pathways; (3) scavenge DNA reactive agents; (4) suppress the abnormal proliferation of early, preneoplastic lesions; and (5) inhibit certain properties of the cancer cell.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(97)04616-8