Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells

We have shown previously that two flavonoids, apigenin and tangeretin, enhance gap junctional intercellular communication (GJIC) in rat liver epithelial cells, named REL cells. Here, we show that these two flavones also antagonize the inhibition of GJIC induced by tumor promoters like 12- O-tetradec...

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Bibliographic Details
Published in:Cancer letters 1997-03, Vol.114 (1), p.207-210
Main Authors: Chaumontet, Catherine, Droumaguet, Catherine, Bex, Valérie, Heberden, Christine, Gaillard-Sanchez, Isabelle, Martel, Paule
Format: Article
Language:English
Subjects:
Animals
Apigenin
Biological and medical sciences
Blotting, Western
Butylated Hydroxytoluene - pharmacology
Carcinogenesis, carcinogens and anticarcinogens
Carcinogens - antagonists & inhibitors
Cells, Cultured
Chamomile
Connexin 43 - metabolism
Dimethyl Sulfoxide - pharmacology
Epithelium - drug effects
Flavones
Flavonoids
Flavonoids - pharmacology
Fluorescent Antibody Technique
Foods and miscellaneous
Gap junction
Gap Junctions - drug effects
Liver - drug effects
Medical sciences
Oils, Volatile - pharmacology
Phosphorylation - drug effects
Plants, Medicinal
Rat liver epithelial (REL) cells
Rats
Tangeretin
Tetradecanoylphorbol Acetate - pharmacology
Tumors
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Summary:We have shown previously that two flavonoids, apigenin and tangeretin, enhance gap junctional intercellular communication (GJIC) in rat liver epithelial cells, named REL cells. Here, we show that these two flavones also antagonize the inhibition of GJIC induced by tumor promoters like 12- O-tetradecanoyl-phorbol-acetate (TPA) and 3,5,di-tertio-butyl-4-hydroxytoluene (BHT). Their preventive effect is rapid. It does not seem to involve any change of the amount of the connexin expressed in REL cells, connexin 43 (Cx 43), and in its phosphorylation state. Other flavonoids tested including naringenin, myricetin, catechin and chrysin did not enhance GJIC nor counteract TPA-induced inhibition of GJIC.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(97)04664-8