α2-Macroglobulin polymorphisms in Italian sporadic and familial Alzheimer's disease

A 5-bp deletion and a Val1000 polymorphism at the α 2-macroglobulin (A2M) gene have recently been reported to be associated with late onset Alzheimer's disease (AD). As recently it has been suggested that the effect of the A2M gene on AD susceptibility may be limited to certain populations or f...

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Bibliographic Details
Published in:Neuroscience letters 2001-02, Vol.299 (1), p.9-12
Main Authors: Nacmias, Benedetta, Tedde, Andrea, Cellini, Elena, Forleo, Paolo, Orlacchio, Antonio, Guarnieri, Bianca Maria, Petruzzi, Concetta, D'Andrea, Francesco, Serio, Antonio, Sorbi, Sandro
Format: Article
Language:English
Subjects:
Alzheimer's disease
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Genetics
Medical sciences
Neurology
Polymorphism
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Summary:A 5-bp deletion and a Val1000 polymorphism at the α 2-macroglobulin (A2M) gene have recently been reported to be associated with late onset Alzheimer's disease (AD). As recently it has been suggested that the effect of the A2M gene on AD susceptibility may be limited to certain populations or families, we analyzed the segregation of A2M and apolipoprotein E polymorphisms in Italian sporadic and familial AD. We analyzed the two polymorphisms in a total of 346 subjects including 98 controls by polymerase chain reaction-restriction fragment length polymorphism method. Our data do not confirm these associations, in particular we found a significant decrease of the deletion allele in AD with respect to controls. Our data do not support a role for the A2M gene as genetic risk factor for AD.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(00)01758-4