Single systemic dose of vigabatrin induces early proconvulsant and later anticonvulsant effect in rats

Vigabatrin (VGB), an inhibitor of gamma-aminobutyric acid-aminotransferase, exhibits an antiepileptic effect but several studies indicate that its effect may be biphasic. A time course of an effect of a single injection of VGB on hippocampal epileptic afterdischarges (AD) elicited by an electric sti...

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Bibliographic Details
Published in:Neuroscience letters 2001-10, Vol.312 (1), p.37-40
Main Authors: STUCHLIK, Ales, KUBOVA, Hana, MARES, Pavel
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Action Potentials - physiology
Animals
Anticonvulsant effect
Anticonvulsants - pharmacology
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Administration Schedule
Electric Stimulation
Electroencephalograph afterdischarges
Electroencephalography - drug effects
Epilepsy
Epilepsy - drug therapy
Epilepsy - metabolism
Epilepsy - physiopathology
gamma-Aminobutyric Acid - drug effects
gamma-Aminobutyric Acid - metabolism
Hippocampus
Hippocampus - drug effects
Hippocampus - metabolism
Hippocampus - physiopathology
Male
Medical sciences
Neurons - drug effects
Neurons - metabolism
Neuropharmacology
Pharmacology. Drug treatments
Proconvulsant effect
Rats
Rats, Wistar
Seizures
Seizures - chemically induced
Seizures - metabolism
Seizures - physiopathology
Vigabatrin
Vigabatrin - pharmacology
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Summary:Vigabatrin (VGB), an inhibitor of gamma-aminobutyric acid-aminotransferase, exhibits an antiepileptic effect but several studies indicate that its effect may be biphasic. A time course of an effect of a single injection of VGB on hippocampal epileptic afterdischarges (AD) elicited by an electric stimulation of the angular bundle was examined in adult rats with chronically implanted electrodes. VGB (600 or 1200 mg/kg intraperitoneally) proved to be an efficient anticonvulsant in the intervals of 24 and 48 h – duration of ADs was shortened and behavioral phenomena were less intense. In contrast, ADs were lengthened 4 h after administration. The biphasic effect of VGB was demonstrated, the initial proconvulsant effect might be due to a different onset of VGB action in individual brain structures, but an additional mechanism of action cannot be excluded.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(01)02195-4