Inhaled nitric oxide induces cerebrovascular effects in anesthetized pigs

• Published in: Neuroscience letters 2003-09, Vol.348 (2), p.85-88
• Main Authors: Kuebler, W.M., Kisch-Wedel, H., Kemming, G.I., Meisner, F., Bruhn, S., Koehler, C., Flondor, M., Messmer, K., Zwissler, B.
• Format: Article
• Language: English
• Subjects: Anesthetics - pharmacology; Animals; Biological and medical sciences; Cerebral Arteries - drug effects; Cerebral Arteries - physiology; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges; Cerebrovascular circulation; Cerebrovascular Circulation - drug effects; Cerebrovascular Circulation - physiology; Drug Administration Routes; Female; Fundamental and applied biological sciences. Psychology; Hemodynamics; Indicator dilution techniques; Indocyanine green; Inhalation therapy; Male; Near-infrared spectroscopy; Nitric oxide; Nitric Oxide - pharmacology; Reaction Time - drug effects; Reaction Time - physiology; Sus scrofa; Vasodilation - drug effects; Vasodilation - physiology; Vertebrates: nervous system and sense organs
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/S0304-3940(03)00722-5

Although inhaled nitric oxide (NO i) is considered to act selectively on pulmonary vessels, EEG abnormalities and even occasional neurotoxic effects of NO i have been proposed. Here, we investigated cerebrovascular effects of increasing concentrations of 5, 10 and 50 ppm NO i in seven anesthetized pigs. Cerebral hemodynamics were assessed non-invasively by use of near-infared spectroscopy and indicator dilution techniques. NO i increased cerebral blood volume significantly and reversibly. This effect was not attributable to changes of macrohemodynamic parameters or arterial blood gases. Simultaneously, cerebral transit time increased while cerebral blood flow remained unchanged. These data demonstrate a vasodilatory action of NO i in the cerebral vasculature, which may occur preferentially in the venous compartment.