Synergy between TGF- β3 and NT-3 to promote the survival of spiral ganglia neurones in vitro

Transforming growth factor- βs (TGF- βs) have been implicated in normal inner ear development and in promoting neuronal survival. Early rat post-natal spiral ganglion cells (SGC) in dissociated cell culture were used as a model of auditory innervation to test the trophic factors TGF- β3 and neurotro...

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Bibliographic Details
Published in:Neuroscience letters 1998, Vol.240 (2), p.77-80
Main Authors: Marzella, P.L, Clark, G.M, Shepherd, R.K, Bartlett, P.F, Kilpatrick, T.J
Format: Article
Language:English
Subjects:
Auditory neurones
Biological and medical sciences
Cytokine
Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation
Fundamental and applied biological sciences. Psychology
Neuronal degeneration
Neurotrophic effects
Neurotrophin
Pharmacological therapy
Vertebrates: nervous system and sense organs
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Summary:Transforming growth factor- βs (TGF- βs) have been implicated in normal inner ear development and in promoting neuronal survival. Early rat post-natal spiral ganglion cells (SGC) in dissociated cell culture were used as a model of auditory innervation to test the trophic factors TGF- β3 and neurotrophin-3 (NT-3) for their ability, individually or in combination, to promote neuronal survival. The findings from this study suggest that TGF- β3 supports neuronal survival in a concentration-dependent manner. Moreover TGF- β3 and NT-3-potentiated spiral ganglion neuronal survival in a synergistic fashion.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(97)00928-2