Identification and characterization of a pyrantel pamoate resistant cyathostome population

Three fecal egg count reduction assays (FECR) and one critical trial were performed to determine the efficacy of pyrantel pamoate (PP) at 6.6 mg base kg −1 on a well managed stud farm in Louisiana where a loss of efficacy was suspected. Efficacy of PP based on FECR varied from 25% in mares to 83% in...

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Bibliographic Details
Published in:Veterinary parasitology 1996-11, Vol.66 (3), p.205-212
Main Authors: Chapman, M.R., French, D.D., Monahan, C.M., Klei, T.R.
Format: Article
Language:English
Subjects:
Animals
Anthelmintic resistance
Antinematodal Agents - therapeutic use
Antinematodal Agents - toxicity
Benzimidazoles - therapeutic use
CABALLOS
CHEVAL
CYATHOSTOMA
Cyathostomes
Drug Resistance
Female
Fenbendazole - therapeutic use
Horse parasites
HORSES
Ivermectin - therapeutic use
LOUISIANA
LOUISIANE
LUISIANA
Male
Parasite Egg Count
PIRANTEL
PYRANTEL
Pyrantel pamoate
Pyrantel Pamoate - therapeutic use
Pyrantel Pamoate - toxicity
RESISTANCE AUX PRODUITS CHIMIQUES
RESISTANCE TO CHEMICALS
RESISTENCIA A PRODUCTOS QUIMICOS
Strongyle Infections, Equine - drug therapy
Strongylus - drug effects
Strongylus - isolation & purification
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Summary:Three fecal egg count reduction assays (FECR) and one critical trial were performed to determine the efficacy of pyrantel pamoate (PP) at 6.6 mg base kg −1 on a well managed stud farm in Louisiana where a loss of efficacy was suspected. Efficacy of PP based on FECR varied from 25% in mares to 83% in yearlings. Second treatments with PP 2 weeks following an initial treatment failed to reduce eggs per gram (EPG). A critical trial was performed to determine the cyathostome species resistant to PP. Three strongyle-naive ponies which acquired infections on the farm were used for this purpose. Following treatment with PP at the recommended dose, 11 species of cyathostomes remained in the intestine of the tracer ponies. Reduced efficacies (62%–88%) were noted for seven species. Resistance to oxibendazole (OBZ), which was > 90% effective on this farm in 1982, was also evaluated by FECR and found to exist. The results of one experiment indicate that dual resistance of parasites to PP and OBZ also exists.
ISSN:0304-4017
1873-2550
DOI:10.1016/S0304-4017(96)01014-X