Methimazole-mediated enhancement of albendazole oral bioavailability and anthelmintic effects against parenteral stages of Trichinella spiralis in mice: the influence of the dose-regime

The influence of methimazole® (MTZ) inhibitor of the microsomal oxidases on the systemic availability of the albendazole sulpho-metabolites (ABZS-MT) albendazole-sulphoxide (ABZSO) and albendazole-sulphone (ABZSO 2) and on its anthelmintic effects was investigated in a mouse model for helminthic inf...

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Bibliographic Details
Published in:Veterinary parasitology 1998-02, Vol.75 (2), p.209-219
Main Authors: López-Garcı́a, Maria L, Torrado, Susana, Torrado, Santiago, Martı́nez, Antonio R, Bolás, Francisco
Format: Article
Language:English
Subjects:
Administration, Oral
Albendazole
Albendazole - administration & dosage
Albendazole - blood
Albendazole - pharmacokinetics
Albendazole-sulphoxide
Animals
ANTHELMINTHIQUE
ANTHELMINTICS
ANTIHELMINTICOS
Antinematodal Agents - administration & dosage
Antinematodal Agents - blood
Antinematodal Agents - pharmacokinetics
Antithyroid Agents - administration & dosage
Antithyroid Agents - blood
Antithyroid Agents - pharmacology
Area Under Curve
BENZIMIDAZOLE
BENZIMIDAZOLES
Biological Availability
Chromatography, High Pressure Liquid - veterinary
Control method-Nematoda
Disease Models, Animal
Drug Interactions
Injections, Intramuscular - veterinary
Methimazole
Methimazole - administration & dosage
Methimazole - blood
Methimazole - pharmacology
MICE
Mouse
Muscles - parasitology
RATON
SOURIS
Systemic availability
TRICHINELLA SPIRALIS
Trichinella spiralis - drug effects
Trichinellosis - drug therapy
Trichinellosis - metabolism
Trichinellosis - veterinary
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Summary:The influence of methimazole® (MTZ) inhibitor of the microsomal oxidases on the systemic availability of the albendazole sulpho-metabolites (ABZS-MT) albendazole-sulphoxide (ABZSO) and albendazole-sulphone (ABZSO 2) and on its anthelmintic effects was investigated in a mouse model for helminthic infections. Plasma concentrations of the ABZS-MT were measured by high performance liquid chromatography (HPLC) following treatment of Swiss CD-1 mice with albendazole (ABZ) alone or ABZ plus MTZ, at both single and repeated doses. The anthelmintic effects were assessed in age-matched mice similarly treated following infection with Trichinella spiralis. MTZ significantly ( p
ISSN:0304-4017
1873-2550
DOI:10.1016/S0304-4017(97)00177-5