Analgesic sesquiterpene dilactone from Mikania cordata

The crude extract of Mikania cordata (1 and 3 g/kg, p.o.) and deoxymikanolide (1) (10 mg/kg, p.o.) significantly inhibited acetic acid-induced writhing in mice. Three other sesquiterpene dilactones isolated from the same plant, namely mikanolide, dihydromikanolide and scandenolide, did not show sign...

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Bibliographic Details
Published in:Fitoterapia 2001-12, Vol.72 (8), p.919-921
Main Authors: Ahmed, M., Rahman, M.T., Alimuzzaman, M., Shilpi, J.A.
Format: Article
Language:English
Subjects:
Acetic Acid
Analgesic activity
Analgesics - administration & dosage
Analgesics - pharmacology
Analgesics - therapeutic use
Animals
Asteraceae
Biological and medical sciences
Dose-Response Relationship, Drug
General pharmacology
Lactones - administration & dosage
Lactones - pharmacology
Lactones - therapeutic use
Male
Medical sciences
Mice
Mikania cordata
Pain - chemically induced
Pain - prevention & control
Pain Measurement - drug effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Sesquiterpene dilactones
Sesquiterpenes - administration & dosage
Sesquiterpenes - pharmacology
Sesquiterpenes - therapeutic use
Sesquiterpenes, Germacrane
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Summary:The crude extract of Mikania cordata (1 and 3 g/kg, p.o.) and deoxymikanolide (1) (10 mg/kg, p.o.) significantly inhibited acetic acid-induced writhing in mice. Three other sesquiterpene dilactones isolated from the same plant, namely mikanolide, dihydromikanolide and scandenolide, did not show significant analgesic activity.
ISSN:0367-326X
DOI:10.1016/S0367-326X(01)00318-5