Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon

We have studied the effect of propolis and its main active ingredient caffeic acid phenetyl ester (CAPE) on formation of aberrant crypt foci (ACF) and tumors in the rat colon in vivo. CAPE (50 mg/kg i.p.) reduced the formation of ACF and tumor induced by azoxymethane, while propolis ethanolic extrac...

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Bibliographic Details
Published in:Fitoterapia 2002-11, Vol.73, p.S38-S43
Main Authors: Borrelli, F., Izzo, A.A., Di Carlo, G., Maffia, P., Russo, A., Maiello, F.M., Capasso, F., Mascolo, N.
Format: Article
Language:English
Subjects:
Aberrant crypt foci
Animals
Anticarcinogenic Agents - administration & dosage
Anticarcinogenic Agents - pharmacology
Anticarcinogenic Agents - therapeutic use
Azoxymethane
Biological and medical sciences
Caffeic Acids - administration & dosage
Caffeic Acids - pharmacology
Caffeic Acids - therapeutic use
CAPE
Colon - drug effects
Colon - pathology
Colonic Neoplasms - chemically induced
Colonic Neoplasms - pathology
Colonic Neoplasms - prevention & control
General pharmacology
Male
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phenylethyl Alcohol - administration & dosage
Phenylethyl Alcohol - analogs & derivatives
Phenylethyl Alcohol - pharmacology
Phenylethyl Alcohol - therapeutic use
Phytotherapy
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Propolis
Propolis - administration & dosage
Propolis - pharmacology
Propolis - therapeutic use
Random Allocation
Rats
Rats, Wistar
Tumors
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Summary:We have studied the effect of propolis and its main active ingredient caffeic acid phenetyl ester (CAPE) on formation of aberrant crypt foci (ACF) and tumors in the rat colon in vivo. CAPE (50 mg/kg i.p.) reduced the formation of ACF and tumor induced by azoxymethane, while propolis ethanolic extract was without effect. These results suggest a potential anti-carcinogenesis of CAPE but not propolis.
ISSN:0367-326X
DOI:10.1016/S0367-326X(02)00189-2