In vitro cytotoxicity of 11 Panamanian plants

Thirty-five crude extracts from 11 Panamanian plants, distributed in 10 genera and five families, were evaluated for their in vitro cytotoxicity. Four extracts exhibited an inhibition of cellular growth at IC 50 values lower than 25 μg/ml which was considered a significant activity.

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Bibliographic Details
Published in:Fitoterapia 2003-06, Vol.74 (4), p.378-383
Main Authors: Calderón, A.I., Terreaux, C., Gupta, M.P., Hostettmann, K.
Format: Article
Language:English
Subjects:
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Breast Neoplasms - drug therapy
Central Nervous System Neoplasms - drug therapy
Cytotoxicity
General pharmacology
H460 (lung carcinoma)
Humans
Inhibitory Concentration 50
Lung Neoplasms - drug therapy
MCF-7 (breast cancer)
Medical sciences
Medicine, Traditional
Panama
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Components, Aerial
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Leaves
Plant Stems
Plants, Medicinal
SF268 (CNS cancer)
Tumor Cells, Cultured - drug effects
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Description
Summary:Thirty-five crude extracts from 11 Panamanian plants, distributed in 10 genera and five families, were evaluated for their in vitro cytotoxicity. Four extracts exhibited an inhibition of cellular growth at IC 50 values lower than 25 μg/ml which was considered a significant activity.
ISSN:0367-326X
DOI:10.1016/S0367-326X(03)00052-2