In vitro cell-toxicity of Peganum harmala alkaloids on cancerous cell-lines

The alkaloidic fraction of the methanol extract of Peganum harmala seeds was tested in vitro on three tumoral cell-lines: UCP-Med and Med-mek Carcinoma, and UCP-Med Sarcoma. Proliferation was significantly reduced at all tested concentrations (20–120 μg/ml) during the first 24 h of contact. A cell l...

Full description

Saved in:
Bibliographic Details
Published in:Fitoterapia 2000-02, Vol.71 (1), p.50-54
Main Authors: Lamchouri, F., Settaf, A., Cherrah, Y., Hassar, M., Zemzami, M., Atif, N., Nadori, E.B., Zaid, A., Lyoussi, B.
Format: Article
Language:English
Subjects:
Alkaloids
Alkaloids - pharmacology
Alkaloids - therapeutic use
Animals
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Agents, Phytogenic - therapeutic use
Biological and medical sciences
Cytotoxicity
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Female
General pharmacology
Male
Medical sciences
Neoplasms, Experimental - prevention & control
Peganum harmala
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - pharmacology
Plants, Medicinal
Rats
Rats, Wistar
Rosales
Seeds
Tumor Cells, Cultured - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The alkaloidic fraction of the methanol extract of Peganum harmala seeds was tested in vitro on three tumoral cell-lines: UCP-Med and Med-mek Carcinoma, and UCP-Med Sarcoma. Proliferation was significantly reduced at all tested concentrations (20–120 μg/ml) during the first 24 h of contact. A cell lysis effect occurred after 24 h and increased thereafter to complete cell death within 48–72 h, depending on tested concentration.
ISSN:0367-326X
DOI:10.1016/S0367-326X(99)00117-3